Wednesday, May 16, 2012


 

 

 Here is an interesting article from the New York Times that makes me wonder how it would fit in with the way of training that protects your brain from too much cortisol. I must admit that I agree more with the need for huff and puff intervals (eg using weights) than I do with cardiovascular over-intensity.


How 1-Minute Intervals Can

Improve Your Health

| February 15, 2012, 12:01 am 279 Comments

While many of us wonder just how much exercise we really need in order to gain health and fitness, a group of scientists in Canada are turning that issue on its head and asking, how little exercise do we need?
The emerging and engaging answer appears to be, a lot less than most of us think — provided we’re willing to work a bit.
In proof of that idea, researchers at McMaster University in Hamilton, Ontario, recently gathered several groups of volunteers. One consisted of sedentary but generally healthy middle-aged men and women. Another was composed of middle-aged and older patients who’d been diagnosed with cardiovascular disease.
The researchers tested each volunteer’s maximum heart rate and peak power output on a stationary bicycle. In both groups, the peaks were not, frankly, very high; all of the volunteers were out of shape and, in the case of the cardiac patients, unwell. But they gamely agreed to undertake a newly devised program of cycling intervals.

Most of us have heard of intervals, or repeated, short, sharp bursts of strenuous activity, interspersed with rest periods. Almost all competitive athletes strategically employ a session or two of interval training every week to improve their speed and endurance.
But the Canadian researchers were not asking their volunteers to sprinkle a few interval sessions into exercise routines. Instead, the researchers wanted the groups to exercise exclusively with intervals.

For years, the American Heart Association and other organizations have recommended that people complete 30 minutes or more of continuous, moderate-intensity exercise, such as a brisk walk, five times a week, for overall good health.
But millions of Americans don’t engage in that much moderate exercise, if they complete any at all. Asked why, a majority of respondents, in survey after survey, say, “I don’t have time.”
Intervals, however, require little time. They are, by definition, short. But whether most people can tolerate intervals, and whether, in turn, intervals provide the same health and fitness benefits as longer, more moderate endurance exercise are issues that haven’t been much investigated.
Several years ago, the McMasters scientists did test a punishing workout, known as high-intensity interval training, or HIIT, that involved 30 seconds of all-out effort at 100 percent of a person’s maximum heart rate. After six weeks, these lacerating HIIT sessions produced similar physiological changes in the leg muscles of young men as multiple, hour-long sessions per week of steady cycling, even though the HIIT workouts involved about 90 percent less exercise time.
Recognizing, however, that few of us willingly can or will practice such straining all-out effort, the researchers also developed a gentler but still chronologically abbreviated form of HIIT. This modified routine involved one minute of strenuous effort, at about 90 percent of a person’s maximum heart rate (which most of us can estimate, very roughly, by subtracting our age from 220), followed by one minute of easy recovery. The effort and recovery are repeated 10 times, for a total of 20 minutes.
Despite the small time commitment of this modified HIIT program, after several weeks of practicing it, both the unfit volunteers and the cardiac patients showed significant improvements in their health and fitness.
The results, published in a recent review of HIIT-related research, were especially remarkable in the cardiac patients. They showed “significant improvements” in the functioning of their blood vessels and heart, said Maureen MacDonald, an associate professor of kinesiology at McMaster who is leading the ongoing experiment.
It might seem counterintuitive that strenuous exercise would be productive or even wise for cardiac patients. But so far none have experienced heart problems related to the workouts, Dr. MacDonald said. “It appears that the heart is insulated from the intensity” of the intervals, she said, “because the effort is so brief.”
Almost as surprising, the cardiac patients have embraced the routine. Although their ratings of perceived exertion, or sense of the discomfort of each individual interval, are high and probably accurate, averaging a 7 or higher on a 10-point scale, they report enjoying the entire sessions more than longer, continuous moderate exercise, Dr. MacDonald said.
“The hard work is short,” she points out, “so it’s tolerable.” Members of a separate, exercise control group at the rehab center, assigned to complete standard 30-minute moderate-intensity workout sessions, have been watching wistfully as the interval trainers leave the lab before them. “They want to switch groups,” she said.
The scientists have noted other benefits in earlier studies. In unfit but otherwise healthy middle-aged adults, two weeks of modified HIIT training prompted the creation of far more cellular proteins involved in energy production and oxygen. The training also improved the volunteers’ insulin sensitivity and blood sugar regulation, lowering their risk of developing Type 2 diabetes, according to a study published last fall in Medicine & Science in Sports & Exercise.
Since then, the scientists completed a small, follow-up experiment involving people with full-blown Type 2 diabetes. They found that even a single bout of the 1-minute hard, 1-minute easy HIIT training, repeated 10 times, improved blood sugar regulation throughout the following day, particularly after meals.
Of course, HIIT training is not ideal or necessary for everyone, said Martin Gibala, a professor of kinesiology at McMaster, who’s overseen the high-intensity studies. “If you have time” for regular 30-minute or longer endurance exercise training, “then by all means, keep it up,” he said. “There’s an impressive body of science showing” that such workouts “are very effective at improving health and fitness.”
But if time constraints keep you from lengthier exercise, he continues, consult your doctor for clearance, and then consider rapidly pedaling a stationary bicycle or sprinting uphill for one minute, aiming to raise your heart rate to about 90 percent of your maximum. Pedal or jog easily downhill for a minute and repeat nine times, perhaps twice a week. “It’s very potent exercise,” Dr. Gibala said. “And then, very quickly, it’s done.”

Sunday, July 13, 2008

Exercise, Cortisol, and Hypercortisolemia

Sports Science research shows that one of the effects of cardiovascular exercise is a significant rise in saliva cortisol levels. For example, Rudolph and McAuley (1998)show cortisol levels rising during a 30 minute treadmill exercise and staying up until 30 minutes afterword.

In addition, Kon et al (2009)research showed this effect is related to the "huffing and puffing" effect since resistance exercise didn't raise cortisol levels unless it occurred in less then normal (hypoxia)oxygen levels.

There is an added problem for someone with hypercortisemia due to a lack of adequate cortisol receptor feedback control. Post exercise high levels of cortisol (hyperpercortisol) don't come down the way they do in normal people. They stay up for prolonged periods of time.

Rudolph and McAuley (1998)show an additional connection that shows up in much of Psychoneuroendcriology research. Psychoneuroendcriology research shows high levels of cortisol are related to negative affect. Going beyond that,other Psychoneuroendcriology research, relate high levels of cortisol that stay up for prolonged periods of time with severe periods of depression and bipolar depression.

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SELECTED RESEARCH EXCERPTS AND COMMENTS
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J Sports Sci. 1998 Feb;16(2):121-8.
Cortisol and affective responses to exercise.
Rudolph DL, McAuley E.
Department of Sport and Exercise Science, University of North Carolina-Greensboro, 27412, USA.

It has been reported that physically active individuals demonstrate attenuated cortisol responses to acute exercise compared to inactive individuals. Furthermore, a number of studies have demonstrated that increased cortisol levels are associated with negative affective states. Conversely, low cortisol levels have been demonstrated to be related to positive psychological constructs such as self-efficacy. However, the roles of activity history and adrenocortical activity in affective responses to acute exercise have not been examined. We therefore compared salivary cortisol, perceived exertion and affective responses to acute exercise in 13 male cross-country runners and 13 non-runners. The experimental trial consisted of a 30 min treadmill run at 60% VO2 max. Cortisol and affective responses were assessed before, during and after exercise; ratings of perceived exertion (RPEs) were recorded during exercise. Analyses of variance indicated no significant group differences in cortisol responses. However, there was a main effect for time (P< 0.05), with cortisol increasing from baseline to the 29th minute of exercise and then decreasing to 30 min post-exercise. Non-runners possessed greater perceptions of effort and negative affect during exercise compared to cross-country runners. Furthermore, the RPEs were positively related to post-exercise cortisol levels (P< 0.05), and affect and cortisol responses were inversely related 30 min post-exercise (P< 0.05). These results provide partial support for the hypothesis that cortisol levels are related to exercise-induced affective states.

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....Many studies have shown that high levels of plasma
and salivary cortisol are associated with negative
psychological states such as depression, dysphoric
mood and panic disorder (Gold et al., 1986; O’Connor
et al., 1989; Lopez et al., 1990).


...The exploratory nature of the present study should
be emphasized, as many competing explanations are
tenable for the positive results linking cortisol and
exercise-induced affect. Despite the cross-sectional
design of the study, these preliminary findings suggest
that physical activity history and adrenocortical activity
play a role in affective responses to acute exercise.

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Med Sci Sports Exerc. 2009 Dec 14. [Epub ahead of print]
Effects of Acute Hypoxia on Metabolic and Hormonal Responses to Resistance Exercise.

Kon M, Ikeda T, Homma T, Akimoto T, Suzuki Y, Kawahara T.

1Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 Nishigaoka, Kita, Tokyo, 115-0056, Japan; 2Laboratory of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan.

INTRODUCTION:: Several recent studies have shown that resistance exercise combined with vascular occlusion effectively causes increases in muscular size and strength. Researchers speculated that the vascular occlusion-induced local hypoxia may contribute to the adaptations via promoting anabolic hormone secretions stimulated by local accumulation of metabolic subproducts. Here we examined whether acute systemic hypoxia affects metabolic and hormonal responses to resistance exercise. METHODS:: Twelve male subjects participated in two experimental trials: 1) resistance exercise while breathing normoxic air [normoxic resistance exercise (NR)], 2) resistance exercise while breathing 13 % oxygen [hypoxic resistance exercise (HR)]. The resistance exercises (bench-press and leg-press) consisted of 10 repetitions for five sets at 70 % of maximum strength with 1-min rest between sets. Blood lactate, serum growth hormone (GH), epinephrine (E), norepinephrine (NE), insulin-like growth factor 1 (IGF-1), testosterone, and cortisol concentrations were
measured before normoxia and hypoxia exposures, 15-min after the exposures, and at 0, 15, 30, 60 min after the exercises. RESULTS:: Lactate significantly increased after exercises in both trials (p < 0.05). In the HR trial, GH and cortisol significantly increased after the exercise (p < 0.05), but not in the NR trial. The E, NE, IGF-1, and testosterone significantly increased after the exercises in both trials (p < 0.05). The mean values of lactate, GH, E, and NE after exercises were significantly higher in the HR trial than that in the NR trial (p <0.05). CONCLUSIONS:: These findings suggest that resistance exercise in hypoxic condition caused greater accumulation of metabolites, and strong anabolic hormone response.

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My interest in this research result was that resistance exercise in a normal oxygen condition does not significantly raise cortisol during or after training. This makes it a useful in designing an adaptive, modified exercise program. That would particularly apply to those with hypercortisolemia.















THE BRAIN AND HYPERCORTISOLEMIA

This blog will be about different aspects of cortisol and the effects of cortisol on the brain.


It will be a review of some of the evidance that high levels of cortisol over prolonged periods of time have a damaging effect on the human brain - especially the hippocampus. I also plan to show that this hypercortisolemia effect interacts with other biochemical variables. Some of these variables will be helpful in diagnosis and treatment of devistating effects of hypercortisolemia from any cause.That would be true for the endocrine glands (Cushing's)or the brain-based glucocorticoid receptors.